A team of researchers from several institutions in Czech Republic has developed a way to determine the absolute stereochemistry (3-D spatial configuration) of small, organic molecules. In their paper ...

A proline derivative reacts with an alkyl iodide to create a complex new molecule with a bond at a key stereocenter in red. A new cross-coupling reaction weds chiral carboxylic acids, such as proline ...

Newly discovered enzymes that are vital for bacterial defenses can also help chemists characterize the stereochemistry in natural products. The enzymes cut proteins between unusual amino acids, ...

Automated reaction path search method predicts accurate stereochemistry of pericyclic reactions using only target molecule structure. Automated reaction path search method predicts accurate ...

We applied the SOSICS approach to generate a panel of stereochemically pure oligonucleotide components of mipomersen (Fig. 1c) to test the impact of stereochemistry on pharmacological parameters.