Lymphocyte development relies on the deliberate induction and precise repair of DNA double-strand breaks (DSBs) to generate the diverse repertoire of antigen receptors that underpin adaptive immunity.

During B and T lymphocyte development, antigen receptor diversity arises through V(D)J recombination, a process driven by the RAG1/2 endonuclease that introduces programmed double-stranded DNA breaks ...

Atypical lymphocytes are types of white blood cells that a person’s immune system produces. They help fight infections and diseases. High levels of atypical lymphocytes may indicate health issues.

Cytotoxic T lymphocytes play a crucial role in adaptive immunity, primarily defending against tumors and viruses. These cells develop within the thymus gland and undergo rapid activation upon ...