WASHINGTON -- Patients with IgG4-related disease appeared to benefit from inebilizumab (Uplizna), currently approved for neuromyelitis optica (NMO), in a pivotal clinical trial. Just 10% of patients ...

The discovery of systemic disease related to raised tissue and serum immunoglobulin G4 (IgG4) is changing diagnostic and therapeutic practice in many medical specialties. Orbital inflammation remains ...

IgG4-related disease (IgG4-RD) is a chronic autoimmune condition that may affect multiple organs in your body, causing tissue swelling and organ damage. Because no single test can definitively ...

The FDA’s approval of inebilizumab has heralded a new era for patients with IgG4-related disease, while novel agents moving ...

To diagnose IgG4-related disease, doctors use a combination of methods, including laboratory tests, clinical evaluation, imaging, and biopsies. Doctors can use imaging and laboratory tests to check ...

Subtype 1 is an IgG4-associated systemic disorder with pancreatic involvement; it is more common in men, especially older men. [14] The symptoms are nonspecific and include mild epigastric abdominal ...

Treatment for IgG4-related disease aims to decrease inflammation and reduce or eliminate signs of the disease. Even in people without symptoms, treatment is necessary to prevent irreversible organ ...

Chemokine (C-C motif) ligand 19 (CCL19) emerged as a biomarker for monitoring disease activity in immunoglobulin (Ig)G4-related disease. Among 12 inflammation-associated proteins with elevated levels ...

IgG4-related disease is an autoimmune disorder affecting millions and has no established cure. Previous research indicates that T cells, a major component of the immune system, and the immunoglobulin ...

Autoimmune pancreatitis typically produces an enlarged pancreas with narrowing of the pancreatic duct, and can mimic carcinoma. Autoimmune pancreatitis usually responds to corticosteroid treatment, ...

In a recent study posted to bioRxiv* preprint server, researchers in Germany assessed the differences in antigen-specific immunoglobulin G (IgG) subtypes between post-COVID syndrome (PCS) patients and ...

Autoimmune diseases are a medical conundrum. In people with these conditions, the immune system of the body, the designated defense system, starts attacking the cells or organs of its own body, ...